Paeoniflorin Attenuated Oxidative Stress in Rat COPD Model Induced by Cigarette Smoke. Evidence-Based Complementary and Alternative Medicine
Jinpei Lin#, Fei Xu#, Genfa Wang, Lingwen Kong, Qingli Luo, Yvbao Lv, Jiaqi Liu, Ying Wei, Lulu Li, Hongying Zhang*, and Jingcheng Dong*
Evidence-Based Complementary and Alternative Medicine. 2016;2016:1698379, 9 pages
Paeoniflorin (PF), amonoterpene glucoside, might have an effect on the oxidative stress.However, themechanism is still unknown. In this study, we made the COPDmodel in Sprague-Dawley (SD) rats by exposing them to the smoke of 20 cigarettes for 1 hour/day and 6 days/week, for 12 weeks, 24 weeks, or 36 weeks. Our findings suggested that smoke inhalation can trigger the oxidative stress from the very beginning. A 24-week treatment of PF especially in the dosage of 40mg/kg⋅d can attenuate oxygen stress by partially quenching reactive oxygen species (ROS) and upregulating antioxidant enzymes via an Nrf2-dependent mechanism.
